| DATE | OPPONENT | SCORE | IP | H | R | ER | BB | K'S | MONEY | OU | RECAP |
| 04/10/2010 | vs Philadelphia | L 6-9 | 5 | 4 | 4 | 4 | 4 | 4 | -$100 | O (9½) | Recap |
| 04/16/2010 | at Chi Cubs | L 2-7 | 6 | 6 | 5 | 5 | 3 | 3 | -$100 | P (9) | Recap |
| 04/22/2010 | vs Florida | L 1-5 | 5⅔ | 6 | 5 | 2 | 3 | 4 | -$110 | U (9) | Recap |
| 04/28/2010 | vs Cincinnati | L 4-6 | 5 | 6 | 6 | 2 | 4 | 4 | -$110 | O (9) | Recap |
| 05/03/2010 | vs Arizona | L 1-9 | 6 | 5 | 4 | 4 | 4 | 8 | -$105 | O (9½) | Recap |
| 05/08/2010 | vs San Diego | L 1-2 | 7 | 5 | 2 | 1 | 0 | 11 | -$100 | U (8½) | Recap |
| 05/14/2010 | at San Francisco | L 2-8 | 4⅔ | 8 | 7 | 7 | 4 | 7 | -$100 | O (8½) | Recap |
| 05/19/2010 | vs Colorado | W 7-3 | 6 | 2 | 2 | 2 | 5 | 4 | $100 | O (9) | Recap |
| 05/25/2010 | at Milwaukee | L 1-6 | 6 | 7 | 2 | 2 | 3 | 4 | -$100 | U (9½) | Recap |
| 05/30/2010 | at Cincinnati | W 2-0 | 8 | 4 | 0 | 0 | 4 | 5 | $185 | U (8½) | Recap |
| 06/04/2010 | vs Chi Cubs | W 3-1 | 8 | 5 | 1 | 1 | 2 | 7 | $105 | U (8) | Recap |
| 06/09/2010 | at Colorado | W 6-2 | 8 | 8 | 2 | 2 | 2 | 7 | $160 | U (9) | Recap |
| 06/15/2010 | at Kansas City | L 7-15 | 4⅔ | 11 | 10 | 8 | 3 | 2 | -$100 | O (9) | Recap |
| 06/20/2010 | vs Texas | L 4-5 | 6 | 10 | 3 | 2 | 2 | 6 | -$100 | O (8) | Recap |
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